Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria. Paroxysmal nocturnal hemoglobinuria pnh is a rare, acquired, lifethreatening disease of the blood characterized by destruction of red blood cells by the complement system, a part of the bodys innate immune system. Dolores fraga fuentes, juan carlos valenzuela gamez. Paroxysmal nocturnal hemoglobinuria pnh is a rare disorder, an acquired chronic hemolytic anemia, often associated with recurrent nocturnal exacerbations, recurrent infections, neutropenia, thrombocytopenia, and episodes of venous thrombosis. Watch in 360 the inside of a nuclear reactor from the size of an atom with virtual reality duration. Hemoglobinuria paroxistica nocturna infobioquimica. Sintomas hemoglobinuria paroxistica nocturna medicinatv. Eculizumab hemoglobinuria paroxistica nocturna astursalud. Scottish charles 1794 cirurgiao strubing paul 1882 urina escura matutina, hemolise intravascular, trombose. The effect of iron therapy in paroxysmal nocturnal hemoglobinuria.
Hemoglobinuria paroxistica nocturna medicina clinica. Hemoglobinuria paroxistica noturna diagnostico e tratamento. Hemoglobinuria paroxistica nocturna linkedin slideshare. Principais sintomas da hemoglobinuria paroxistica noturna e. Marchiafava, 1911 michelli, 1931 anemia hemolitica com esplenomegalia e hemoglobinuria e hemosiderinuria ham th, dingle jh. Hemoglobinuria trombosis venosa arterial tvp ictusait cerebralcardiaca hepaticaportal mesenterica. Apr 30, 2014 watch in 360 the inside of a nuclear reactor from the size of an atom with virtual reality duration. Paroxysmal nocturnal hemoglobinuria internal medicine usmle step 2.
Hemoglobinuria paroxistica nocturna h p n definicion. Arango elkin fernando, arroyave claudia lucia, zuleta john jairo, restrepo maria victoria, lopera antonio jose, zuluaga hector, botero juan pablo, zapata silvia. Gaona c gaona, carlos almaguer hemoglobinuria paroxistica nocturna. Paroxysmal nocturnal hemoglobinuria pnh is an acquired clonal hematopoietic stem cell disorder characterized by corpuscular hemolytic anemia, bone. Hpn flaer gpi abstract paroxysmal nocturnal hemoglobinuria pnh is an acquired clonal disease caused by the somatic mutation of the piga gene, located at the end of the short arm of.
Hemoglobinuria paroxistica nocturna by prezi user on. Mar, 2016 16 hemoglobinuria paroxistica nocturna dra diana otero. This destructive process occurs due to the presence of defective surface protein daf on the red blood cell, which normally functions to inhibit such immune reactions. Circulating primitive stem cells in paroxysmal nocturnal hemoglobinuria pnh are predominantly normal in phenotype but granulocyte colonystimulating factor treatment mobilizes mainly pnh stem cells. Causas hemoglobinuria paroxistica nocturna medicinatv. Hemoglobinuria paroxistica nocturna by prezi user on prezi. The paroxysmal nocturnal hemoglobinuria is an infrequent cause of pancytopenia.